Five people were taken to hospital following a six-vehicle pile-up on the A68 at Soutra Hill last night.
The crash happened at about 5.10pm when a Honda Civic travelling north was involved in a collision with the other vehicles.
Police say the Honda driver and passenger sustained serious injuries and were among the five taken to Edinburgh Royal Hospital.
A further five people were treated at the scene by ambulance staff.
The road was closed for several hours for investigations.
Sergeant Roger Park, from Police Scotland’s National Trunk Road Patrol Group, said: “In the immediate aftermath of the collision a number of motorists stopped to provide assistance to the injured, and I would like to thank them for their help, and for remaining at the scene in order to assist responding officers.
“The road was closed for a number of hours while inquiries took place at the scene, and an investigation into the cause of the collision is ongoing.
“At this time I would appeal to anyone who witnessed the collision, or who thinks they have any relevant information that would assist our inquiries, to contact Police Scotland on 101.”